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Title   Cisplatin 병합 화학요법시 급성 진토효과에 대한 Ondansetron 과 Metoclopramide , Dexamethasone , Lorazepam 병용요법의 비교 ( A Comparison of the Acute Antiemetic Effect of Ondansetron with Combination of Metoclopramide , Dexamethasone , Lorazepam in Patients Receiving Cisplatin
Publicationinfo   1992 Jan; 024(05): 759-766.
Key_word   High-dose cisplatin, Ondansetron, MDL therapy
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Abstract   Background, In spite of possible effects for emesis following chemotherapy including high dose cisplatin, nausea and vomiting are the most troublesome problem in cancer treatment. Ondansetron, a selective antagonist of serotonin S, receptors, is effective in the prevention of emesis associated with chemotherapeutic agents, especially high dose cisplatin. Methods. 19 patients with solid cancer scheduled to receive cisplatin containing chemotherapy were studied, and we compared the efficacy and safety of ondansetron with those of intra- venous high dose metoclopramide(1.5 mg/kg) plus dexamethasone(10 mg i.v.) and lorazepam (2 mg i.v.) (MDL therapy) to control the acute emesis induced by high-dose cisplatin(>50 mg/m -) treatment. Ondansetron was administered in dose of 8 mg intravenous bolus followed by a in- fusion of 1 mg/hour 24 hours as recommended schedule for the prophylaxis of acute cisplatin- induced emesis. Results. Ondansetron showed significantly greater rate of the complete response than that of MDL therapy(63.2% vs 31.6%) for contro1ling of acute emesis on the first day of treatment(p<0.05). Also ondansetron showed significantly lower grade of nausea than in comparable MDL therapy(p< 0.05). Side effects attributable to ondansetron were mild: headache in 4 patients, diarrhea in 1 patient, sedation in 1 patient and abdominal pain in 1 patient. Therefore, ondansetron exhibited minimal toxicity with no extrapyramidal effects. Conclusions. Ondansetron was well tolerable and at least as effective as MDL therapy in controlling acute cisplatin-induced emesis.
저 자   백승호(Seung Ho Baik),차미경(Mi Kyung Cha),조용욱(Yong Wook Cho),오도현(Do Yeun Oh),김선주(Sun Joo Kim)